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Design of an in vitro biocatalytic cascade for the manufacture of islatravir

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Science  06 Dec 2019:
Vol. 366, Issue 6470, pp. 1255-1259
DOI: 10.1126/science.aay8484

Article Information

vol. 366 no. 6470 1255-1259

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 12, 2019
  • Accepted for publication October 24, 2019
  • .

Author Information

  1. Mark A. Huffman1,*,
  2. Anna Fryszkowska1,*,
  3. Oscar Alvizo2,
  4. Margie Borra-Garske2,
  5. Kevin R. Campos1,
  6. Keith A. Canada1,
  7. Paul N. Devine1,
  8. Da Duan2,
  9. Jacob H. Forstater1,
  10. Shane T. Grosser1,
  11. Holst M. Halsey1,
  12. Gregory J. Hughes1,
  13. Junyong Jo1,
  14. Leo A. Joyce1,,
  15. Joshua N. Kolev1,
  16. Jack Liang2,
  17. Kevin M. Maloney1,
  18. Benjamin F. Mann1,
  19. Nicholas M. Marshall1,,
  20. Mark McLaughlin1,
  21. Jeffrey C. Moore1,
  22. Grant S. Murphy1,
  23. Christopher C. Nawrat1,
  24. Jovana Nazor2,
  25. Scott Novick2,
  26. Niki R. Patel1,
  27. Agustina Rodriguez-Granillo3,§,
  28. Sandra A. Robaire1,
  29. Edward C. Sherer3,
  30. Matthew D. Truppo1,,
  31. Aaron M. Whittaker1,
  32. Deeptak Verma3,
  33. Li Xiao3,
  34. Yingju Xu1,
  35. Hao Yang1
  1. 1Process Research and Development, Merck & Co., Inc., Rahway, NJ 07065, USA.
  2. 2Codexis, Inc., 200 Penobscot Drive, Redwood City, CA 94063, USA.
  3. 3Computational and Structural Chemistry, Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ 07033, USA.
  1. *Corresponding author. Email: mark_huffman{at}merck.com (M.A.H.); anna.fryszkowska{at}merck.com (A.F.)
  • Present address: Arrowhead Pharmaceuticals, 502 South Rosa Road, Madison, WI 53719, USA.

  • Present address: Invenra, 505 South Rosa Road, Madison, WI 53719, USA.

  • § Present address: Schrodinger, 222 Third St, Cambridge, MA 02142, USA.

  • Present address: Janssen Research & Development, Spring House, PA 19477, USA.

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Article usage: December 2019 to April 2020

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Dec 2019958336582892
Jan 20202575850724
Feb 20202161660535
Mar 20201216386442
Apr 2020524454

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