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VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

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Science  20 Dec 2019:
Vol. 366, Issue 6472, pp. 1531-1536
DOI: 10.1126/science.aav4011

Article Information

vol. 366 no. 6472 1531-1536

PubMed: 
Print ISSN: 
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History: 
  • Received for publication September 21, 2018
  • Resubmitted July 9, 2019
  • Accepted for publication October 29, 2019
  • .

Author Information

  1. Jeonghan Kim1,
  2. Rajeev Gupta2,
  3. Luz P. Blanco3,
  4. Shutong Yang1,
  5. Anna Shteinfer-Kuzmine2,
  6. Kening Wang4,
  7. Jun Zhu5,7,
  8. Hee Eun Yoon1,
  9. Xinghao Wang3,
  10. Martijn Kerkhofs6,
  11. Hyeog Kang1,
  12. Alexandra L. Brown1,
  13. Sung-Jun Park1,
  14. Xihui Xu1,
  15. Eddy Zandee van Rilland1,*,
  16. Myung K. Kim1,
  17. Jeffrey I. Cohen4,
  18. Mariana J. Kaplan3,
  19. Varda Shoshan-Barmatz2,
  20. Jay H. Chung1,
  1. 1Laboratory of Obesity and Aging Research, Cardiovascular Branch, National Heart Lung and Blood Institute, Bethesda, MD 20892, USA.
  2. 2Department of Life Sciences and National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
  3. 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20982, USA.
  4. 4Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
  5. 5Systems Biology Center, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
  6. 6Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, and Leuven Kanker Instituut, KU Leuven, 3000 Leuven, Belgium.
  7. 7Mokobio Biotechnology R&D Center, Rockville, MD 20850, USA.
  1. Corresponding author. Email: chungj{at}nhlbi.nih.gov
  • * Present address: Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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