A recruitment center for biorepair

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Science  10 Jan 2020:
Vol. 367, Issue 6474, pp. 159-160
DOI: 10.1126/science.367.6474.159-f

Although it is possible to incorporate tissue-specific cells into a biomaterial for tissue repair, it requires cell isolation and expansion and a way to constrain the cells after implantation. An alternative option would be a biomaterial that harnesses and accelerates the body's own capabilities for repair. Adenosine is found throughout the body, but its concentration will temporarily and locally spike after a tissue injury because it acts as an extracellular signaling molecular to encourage repair. Because boronate molecules bond to and sequester adenosine, Zeng et al. developed a polymeric material that incorporates 3-(acrylamido) phenylboronic acid. When implanted as a patch at the site of a bone injury, the polymer maintained an increased level of adenosine, thus promoting osteoblastogenesis and angiogenesis.

Adv. Mat. 10.1002/adma.201906022 (2019).

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