Programmed cell death along the midline axis patterns ipsilaterality in gastrulation

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Science  10 Jan 2020:
Vol. 367, Issue 6474, pp. 197-200
DOI: 10.1126/science.aaw2731

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Apoptosis prevents left-right crossing

Animals generally display a bilateral body plan, with symmetry between the left and right sides. Maya-Ramos and Mikawa examined the mechanism that prevents the crossing of cells between sides. Using chick embryos, they show that cellular mixing between sides is prevented by a barrier at the embryonic midline that involves programmed cell death and the extracellular matrix. This work demonstrates the dependence of normal development on programmed cell death during the gastrulation stage.

Science, this issue p. 197

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