Effect of tolerance on the evolution of antibiotic resistance under drug combinations

See allHide authors and affiliations

Science  10 Jan 2020:
Vol. 367, Issue 6474, pp. 200-204
DOI: 10.1126/science.aay3041

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Challenges of drug combinations

Combinations of antibiotics are used to treat intractable infections such as methicillin-resistant Staphylococcus aureus. Clinically, however, drugs tend to be used empirically, and results can be contradictory. Liu et al. translated observations made in vitro to patient samples to understand the role of antibiotic tolerance in promoting or suppressing resistance when drug combinations are used (see the Perspective by Berti and Hirsch). Although bacterial populations exposed to multiple antibiotics can develop tolerance to multiple drugs, one drug in a combination may be able counter resistance to a partner drug and provide effective therapy. However, if tolerance has already emerged to one drug, the combination may end up promoting the transmission of resistance to a partner drug.

Science, this issue p. 200; see also p. 141

View Full Text

Stay Connected to Science