Research Article

Single-cell transcriptional diversity is a hallmark of developmental potential

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Science  24 Jan 2020:
Vol. 367, Issue 6476, pp. 405-411
DOI: 10.1126/science.aax0249

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More diversity at the top

A detailed knowledge of cell differentiation hierarchies is important for understanding diverse biological processes such as organ development, tissue regeneration, and cancer. Single-cell RNA sequencing can help elucidate these hierarchies, but it requires reliable computational methods for predicting cell lineage trajectories. Gulati et al. developed CytoTRACE, a computational framework based on the simple observation that transcriptional diversity—the number of genes expressed in a cell—decreases during differentiation. CytoTRACE outperformed other methods in several test cases and was successfully applied to study cellular hierarchies in healthy and tumor tissue.

Science, this issue p. 405

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