Report
An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors
- View ORCID ProfileKatharina Reinhard1,*,
- View ORCID ProfileBenjamin Rengstl1,*,
- View ORCID ProfilePetra Oehm1,*,
- Kristina Michel1,
- View ORCID ProfileArne Billmeier1,
- Nina Hayduk1,
- Oliver Klein1,
- Kathrin Kuna1,
- Yasmina Ouchan1,
- Stefan Wöll1,
- Elmar Christ1,
- David Weber2,
- Martin Suchan2,
- View ORCID ProfileThomas Bukur2,
- Matthias Birtel1,
- Veronika Jahndel1,
- Karolina Mroz1,
- Kathleen Hobohm1,
- Lena Kranz1,
- Mustafa Diken2,
- Klaus Kühlcke1,
- View ORCID ProfileÖzlem Türeci1,†,
- View ORCID ProfileUgur Sahin1,2,3,†,‡
- 1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
- 2TRON–Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstr. 12, 55131 Mainz, Germany.
- 3Helmholtz Institute for Translational Oncology Mainz, HI-TRON Mainz, Obere Zahlbacher Str. 63, 55131 Mainz, Germany.
- ↵‡Corresponding author. Email: ugur.sahin{at}biontech.de
See allHide authors and affiliations
Science 24 Jan 2020:
Vol. 367, Issue 6476, pp. 446-453
DOI: 10.1126/science.aay5967
Vol. 367, Issue 6476, pp. 446-453
DOI: 10.1126/science.aay5967
Katharina Reinhard
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Benjamin Rengstl
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Petra Oehm
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Kristina Michel
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Arne Billmeier
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Nina Hayduk
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Oliver Klein
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Kathrin Kuna
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Yasmina Ouchan
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Stefan Wöll
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Elmar Christ
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
David Weber
2TRON–Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstr. 12, 55131 Mainz, Germany.
Martin Suchan
2TRON–Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstr. 12, 55131 Mainz, Germany.
Thomas Bukur
2TRON–Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstr. 12, 55131 Mainz, Germany.
Matthias Birtel
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Veronika Jahndel
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Karolina Mroz
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Kathleen Hobohm
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Lena Kranz
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Mustafa Diken
2TRON–Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstr. 12, 55131 Mainz, Germany.
Klaus Kühlcke
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Özlem Türeci
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
Ugur Sahin
1Biopharmaceutical New Technologies (BioNTech) Corporation, BioNTech Cell & Gene Therapies GmbH, BioNTech Innovative Manufacturing Services GmbH, An der Goldgrube 12, 55131 Mainz, Germany.
2TRON–Translational Oncology at the University Medical Center of Johannes Gutenberg University gGmbH, Freiligrathstr. 12, 55131 Mainz, Germany.
3Helmholtz Institute for Translational Oncology Mainz, HI-TRON Mainz, Obere Zahlbacher Str. 63, 55131 Mainz, Germany.