Research Article

Chromatin accessibility dynamics in a model of human forebrain development

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Science  24 Jan 2020:
Vol. 367, Issue 6476, eaay1645
DOI: 10.1126/science.aay1645

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  • RE: Chromatin acessibility dynamics in a model of human forebrain development

    Dear Editor,
    This comprehensive and innovative report clearly showed the developmental events in the human brain by 3-D modelling. While neurons and glia are already formed during the fetal period the maturation goes on long in the postnatal period. For instance the myelin maturation continues into the late teens (Savolainen et al., Brain Res 37: 253, 1972). Likewise, the pruning of the supernumerary synapses is clearly associated with the learning processes.
    Much of the brain disorders also have epigenetic and other environmental interactive aspects which is why the prediction by biochemical methods is complex.

    Competing Interests: None declared.

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