PerspectiveInfectious Disease

No hasty solutions for African swine fever

See allHide authors and affiliations

Science  07 Feb 2020:
Vol. 367, Issue 6478, pp. 622-624
DOI: 10.1126/science.aaz8590

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

An epidemic of African swine fever (ASF), a lethal viral hemorrhagic disease of swine, is devastating pig production in Asia and is a global threat. The ASF virus (ASFV) reached the European Union (EU) in 2014, affecting pig production. ASFV continues to spread through wild boar (Sus scrofa), which form interconnected populations across Europe and which maintain the infection and can cause infection in pigs. A vaccine is not yet available and is urgently needed, both for pigs and wild boar. Live attenuated virus (LAV) vaccines are the most promising way forward in the short term (1), and recent advances have been made in constructing gene-deleted LAV vaccines. Naturally attenuated LAVs have also been shown to confer protection as vaccines in pigs and wild boar. However, previous experience with vaccination failures using naturally attenuated LAVs emphasizes the need for caution because of safety concerns.

View Full Text

Stay Connected to Science