Active tumor penetration

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Science  07 Feb 2020:
Vol. 367, Issue 6478, pp. 638-639
DOI: 10.1126/science.367.6478.638-c

Anticancer nanoparticle development has relied on the assumption that nanoparticles passively cross leaky blood vessels to enter solid tumors. Using transmission electron microscopy to analyze a glioblastoma xenograft model, Sindhwani et al. found that gaps between endothelial cells lining blood vessels are infrequent and do not account for observed nanoparticle accumulation in tumors. Instead, nanoparticles actively enter tumors by transendothelial extravasation. They also show that the vascular architecture in human tumor samples is mostly intact, which supports the observations that nanoparticles enter tumors by means of an active process rather than by a generalized leakiness.

Nat. Mater. 10.1038/s41563-019-0566-2 (2020).

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