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Microglia mediate forgetting via complement-dependent synaptic elimination

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Science  07 Feb 2020:
Vol. 367, Issue 6478, pp. 688-694
DOI: 10.1126/science.aaz2288

Article Information

vol. 367 no. 6478 688-694

PubMed: 
Print ISSN: 
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History: 
  • Received for publication August 27, 2019
  • Accepted for publication January 6, 2020
  • .

Author Information

  1. Chao Wang1,2,*,
  2. Huimin Yue1,2,*,
  3. Zhechun Hu1,2,
  4. Yuwen Shen1,2,
  5. Jiao Ma3,
  6. Jie Li1,2,
  7. Xiao-Dong Wang4,5,
  8. Liang Wang6,
  9. Binggui Sun7,
  10. Peng Shi8,
  11. Lang Wang3,,
  12. Yan Gu1,2,9,
  1. 1Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
  2. 2Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.
  3. 3Department of Neurology of the First Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou 310029, China.
  4. 4Department of Neurobiology, Institute of Neuroscience, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
  5. 5Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
  6. 6Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital, Mental Health Center, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
  7. 7Center for Neuroscience and Department of Neurology of the First Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou 310058, China.
  8. 8Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
  9. 9Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, Hangzhou 310058, China.
  1. Corresponding author. Email: wanglang{at}zju.edu.cn (L.W.); guyan2015{at}zju.edu.cn (Y.G.)
  1. * These authors contributed equally to this work.

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