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Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

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Science  07 Feb 2020:
Vol. 367, Issue 6478, pp. 694-699
DOI: 10.1126/science.aaw8653

Article Information

vol. 367 no. 6478 694-699

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History: 
  • Received for publication February 16, 2019
  • Resubmitted August 30, 2019
  • Accepted for publication January 6, 2020
  • .

Author Information

  1. Erik W. Martin1,*,
  2. Alex S. Holehouse2,3,*,
  3. Ivan Peran1,*,
  4. Mina Farag2,3,
  5. J. Jeremias Incicco4,
  6. Anne Bremer1,
  7. Christy R. Grace1,
  8. Andrea Soranno3,4,
  9. Rohit V. Pappu2,3,,
  10. Tanja Mittag1,
  1. 1Department of Structural Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  2. 2Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
  3. 3Center for Science & Engineering of Living Systems (CSELS), Washington University in St. Louis, St. Louis, MO 63130, USA.
  4. 4Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
  1. Corresponding author. Email: pappu{at}wustl.edu (R.V.P.); tanja.mittag{at}stjude.org (T.M.)
  1. * These authors contributed equally to this work.

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