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Structural basis of second-generation HIV integrase inhibitor action and viral resistance

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Science  14 Feb 2020:
Vol. 367, Issue 6479, pp. 806-810
DOI: 10.1126/science.aay4919

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vol. 367 no. 6479 806-810

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History: 
  • Received for publication June 23, 2019
  • Accepted for publication January 15, 2020
  • .

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Author Information

  1. Nicola J. Cook1,
  2. Wen Li2,3,
  3. Dénes Berta4,
  4. Magd Badaoui4,
  5. Allison Ballandras-Colas1,
  6. Andrea Nans5,
  7. Abhay Kotecha6,7,
  8. Edina Rosta4,
  9. Alan N. Engelman2,3,*,
  10. Peter Cherepanov1,8,*
  1. 1Chromatin Structure and Mobile DNA Laboratory, Francis Crick Institute, London NW1 1AT, UK.
  2. 2Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  3. 3Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Department of Chemistry, King’s College London, London SE1 1DB, UK.
  5. 5Structural Biology Science Technology Platform, Francis Crick Institute, London NW1 1AT, UK.
  6. 6The Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  7. 7Materials and Structural Analysis, Thermo Fisher Scientific, Eindhoven, 5651 GG, Netherlands.
  8. 8Department of Infectious Disease, Imperial College London, St Mary’s Campus, London W2 1PG, UK.
  1. *Corresponding author. Email: peter.cherepanov{at}crick.ac.uk (P.C.); alan_engelman{at}dfci.harvard.edu (A.N.E.)

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