An atlas of the protein-coding genes in the human, pig, and mouse brain

Evelina Sjöstedt; Wen Zhong; Linn Fagerberg; Max Karlsson; Nicholas Mitsios; Csaba Adori; Per Oksvold; Fredrik Edfors; Agnieszka Limiszewska; Feria Hikmet; Jinrong Huang; Yutao Du; Lin Lin; Zhanying Dong; Ling Yang; Xin Liu; Hui Jiang; Xun Xu; Jian Wang; Huanming Yang; Lars Bolund; Adil Mardinoglu; Cheng Zhang; Kalle von Feilitzen; Cecilia Lindskog; Fredrik Pontén; Yonglun Luo; Tomas Hökfelt; Mathias Uhlén; Jan Mulder

doi:10.1126/science.aay5947

Research Article

An atlas of the protein-coding genes in the human, pig, and mouse brain

View ORCID ProfileEvelina Sjöstedt¹,²,
View ORCID ProfileWen Zhong²,
View ORCID ProfileLinn Fagerberg²,
View ORCID ProfileMax Karlsson²,
View ORCID ProfileNicholas Mitsios¹,
Csaba Adori¹,
View ORCID ProfilePer Oksvold²,
View ORCID ProfileFredrik Edfors²,
View ORCID ProfileAgnieszka Limiszewska¹,
View ORCID ProfileFeria Hikmet³,
View ORCID ProfileJinrong Huang⁴,⁵,⁶,⁷,
Yutao Du⁵,⁸,
View ORCID ProfileLin Lin⁴,⁶,
Zhanying Dong⁴,⁵,⁶,
View ORCID ProfileLing Yang⁴,⁵,⁶,
View ORCID ProfileXin Liu⁵,⁸,
Hui Jiang⁹,
View ORCID ProfileXun Xu⁵,⁸,
Jian Wang⁵,⁸,
View ORCID ProfileHuanming Yang⁵,⁸,
Lars Bolund⁴,⁵,⁶,
View ORCID ProfileAdil Mardinoglu²,
View ORCID ProfileCheng Zhang²,
View ORCID ProfileKalle von Feilitzen²,
View ORCID ProfileCecilia Lindskog³,
View ORCID ProfileFredrik Pontén³,
View ORCID ProfileYonglun Luo⁴,⁵,⁶,
Tomas Hökfelt¹,
View ORCID ProfileMathias Uhlén ¹,²,*,†,
View ORCID ProfileJan Mulder¹,*,†

¹Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.
²Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.
³Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
⁴Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.
⁵BGI-Shenzhen, Shenzhen 518083, China.
⁶Department of Biomedicine, Aarhus University, 80000 Aarhus, Denmark.
⁷Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.
⁸China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China.
⁹MGI, BGI-Shenzhen, Shenzhen 518083, China.

↵†Corresponding author. Email: mathias.uhlen{at}scilifelab.se (M.U.); jan.mulder{at}ki.se (J.M.)

↵* These authors contributed equally to this work.

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Science 06 Mar 2020:
Vol. 367, Issue 6482, eaay5947
DOI: 10.1126/science.aay5947

Evelina Sjöstedt

1Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

2Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

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Wen Zhong

2Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

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Linn Fagerberg

2Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

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Max Karlsson

2Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

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Nicholas Mitsios

1Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

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Csaba Adori

1Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

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Per Oksvold

2Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

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Fredrik Edfors

2Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

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Agnieszka Limiszewska

1Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

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Feria Hikmet

3Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.

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Jinrong Huang

4Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.

5BGI-Shenzhen, Shenzhen 518083, China.

6Department of Biomedicine, Aarhus University, 80000 Aarhus, Denmark.

7Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.

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Yutao Du

5BGI-Shenzhen, Shenzhen 518083, China.

8China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China.

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Lin Lin

4Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.

6Department of Biomedicine, Aarhus University, 80000 Aarhus, Denmark.

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Zhanying Dong

4Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.

5BGI-Shenzhen, Shenzhen 518083, China.

6Department of Biomedicine, Aarhus University, 80000 Aarhus, Denmark.

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Ling Yang

4Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.

5BGI-Shenzhen, Shenzhen 518083, China.

6Department of Biomedicine, Aarhus University, 80000 Aarhus, Denmark.

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Xin Liu

5BGI-Shenzhen, Shenzhen 518083, China.

8China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China.

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Hui Jiang

9MGI, BGI-Shenzhen, Shenzhen 518083, China.

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Xun Xu

5BGI-Shenzhen, Shenzhen 518083, China.

8China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China.

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Jian Wang

5BGI-Shenzhen, Shenzhen 518083, China.

8China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China.

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Huanming Yang

5BGI-Shenzhen, Shenzhen 518083, China.

8China National GeneBank, BGI-Shenzhen, Shenzhen 518083, China.

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Lars Bolund

4Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.

5BGI-Shenzhen, Shenzhen 518083, China.

6Department of Biomedicine, Aarhus University, 80000 Aarhus, Denmark.

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Adil Mardinoglu

2Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

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Cheng Zhang

2Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

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Kalle von Feilitzen

2Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

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Cecilia Lindskog

3Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.

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Fredrik Pontén

3Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.

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Yonglun Luo

4Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao 266555, China.

5BGI-Shenzhen, Shenzhen 518083, China.

6Department of Biomedicine, Aarhus University, 80000 Aarhus, Denmark.

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Tomas Hökfelt

1Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

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Mathias Uhlén

1Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

2Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, 17121 Stockholm, Sweden.

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For correspondence: mathias.uhlen@scilifelab.se jan.mulder@ki.se

Jan Mulder

1Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

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For correspondence: mathias.uhlen@scilifelab.se jan.mulder@ki.se

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An atlas of the protein-coding genes in the human, pig, and mouse brain

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