Signaling

A decoy insulin receptor in worms?

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Science  20 Mar 2020:
Vol. 367, Issue 6484, pp. 1337-1338
DOI: 10.1126/science.367.6484.1337-g

Insulin signaling in the worm Caenorhabditis elegans appears to be regulated by expression of a truncated, alternatively spliced form of the receptor that lacks the intracellular signaling domain of the receptor. Expression of the spliced form of the receptor, DAF-2B, is regulated in the worm and serves to modulate the effects of insulin-like peptides. Expression of DAF-2B alters sensitivity to insulin. Martinez et al. suggest that the modified receptor might alter insulin signaling by sequestering insulin peptides on the inactive receptor, although such binding was not shown. Interaction with the full-length receptor is also a possibility. The results raise the intriguing possibility that a spliced receptor might function similarly in mammals and contribute to the control of insulin signaling.

eLife 9, e49917 (2020).

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