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Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division

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Science  20 Mar 2020:
Vol. 367, Issue 6484, pp. 1366-1371
DOI: 10.1126/science.aax6089

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PI(4)P regulates mitochondrial fission

Mitochondria are dynamic intracellular organelles, the shape and number of which are regulated by various cell-signaling pathways. Mitochondrial division is driven by the recruitment of a constricting guanosine triphosphatase protein at sites of contact with the endoplasmic reticulum, but other factors, including lysosomes, are also involved. Nagashima et al. now document an essential role for Golgi-derived vesicles bearing a specific lipid—phosphatidylinositol 4-phosphate, or PI(4)P—in the final steps of mitochondrial division. Disruption of PI(4)P production results in mitochondrial morphological defects indicative of an inability to complete fission.

Science, this issue p. 1366

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