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Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing

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Science  10 Apr 2020:
Vol. 368, Issue 6487, pp. 186-189
DOI: 10.1126/science.aau6481

Article Information

vol. 368 no. 6487 186-189

PubMed: 
Print ISSN: 
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History: 
  • Received for publication July 9, 2018
  • Resubmitted August 22, 2019
  • Accepted for publication February 11, 2020
  • .

Author Information

  1. Nicholas J. Bessman1,2,3,
  2. Jacques R. R. Mathieu4,5,*,
  3. Cyril Renassia4,5,*,
  4. Lei Zhou1,2,3,
  5. Thomas C. Fung1,2,3,
  6. Keith C. Fernandez1,2,3,
  7. Christine Austin6,
  8. Jesper B. Moeller1,2,3,7,
  9. Sara Zumerle4,5,,
  10. Sabine Louis4,5,
  11. Sophie Vaulont4,5,
  12. Nadim J. Ajami8,
  13. Harry Sokol9,
  14. Gregory G. Putzel1,
  15. Tara Arvedson10,
  16. Robbyn E. Sockolow11,
  17. Samira Lakhal-Littleton12,
  18. Suzanne M. Cloonan13,14,
  19. Manish Arora6,
  20. Carole Peyssonnaux4,5,,
  21. Gregory F. Sonnenberg1,2,3,
  1. 1Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, Cornell University, New York, NY, USA.
  2. 2Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
  3. 3Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
  4. 4Université de Paris, INSERM U1016, Institut Cochin, CNRS UMR8104, 75014 Paris, France.
  5. 5Laboratory of Excellence GR-Ex, Paris, France.
  6. 6Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  7. 7Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
  8. 8MD Anderson Cancer Center, Houston, TX, USA.
  9. 9Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint Antoine, Service de Gastroenterologie, F-75012 Paris, France.
  10. 10Department of Oncology Research, Amgen Inc., Thousand Oaks, CA, USA.
  11. 11Department of Pediatrics, Division of Gastroenterology and Nutrition, Weill Cornell Medicine, Cornell University, New York, NY, USA.
  12. 12Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.
  13. 13Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
  14. 14Trinity College Dublin, Dublin, Ireland.
  1. Corresponding author. Email: gfsonnenberg{at}med.cornell.edu (G.F.S.); carole.peyssonnaux{at}inserm.fr (C.P.)
  1. * These authors contributed equally to this work.

  • Present address: Department of Medicine, University of Padova and VIMM Veneto Institute of Molecular Medicine, Padova, Italy.

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