Research Article

Mechanisms generating cancer genome complexity from a single cell division error

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Science  17 Apr 2020:
Vol. 368, Issue 6488, eaba0712
DOI: 10.1126/science.aba0712

Article Information

vol. 368 no. 6488

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History: 
  • Received for publication November 1, 2019
  • Accepted for publication March 4, 2020
  • .

Author Information

  1. Neil T. Umbreit1,2,3,*,,
  2. Cheng-Zhong Zhang4,5,*,,
  3. Luke D. Lynch2,3,,
  4. Logan J. Blaine2,3,,
  5. Anna M. Cheng1,2,3,
  6. Richard Tourdot4,5,
  7. Lili Sun6,
  8. Hannah F. Almubarak4,5,
  9. Kim Judge7,
  10. Thomas J. Mitchell7,8,
  11. Alexander Spektor2,3,9,
  12. David Pellman1,2,3,
  1. 1Howard Hughes Medical Institute, Chevy Chase, MD, USA.
  2. 2Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
  3. 3Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  4. 4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  5. 5Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.
  6. 6Single-Cell Sequencing Program, Dana-Farber Cancer Institute, Boston, MA, USA.
  7. 7Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.
  8. 8Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
  9. 9Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  1. Corresponding authors. Email: neilt_umbreit{at}dfci.harvard.edu (N.T.U.); david_pellman{at}dfci.harvard.edu (D.P.); cheng-zhong_zhang{at}dfci.harvard.edu (C.-Z.Z.)
  1. * These authors contributed equally to this work.

  2. These authors contributed equally to this work.

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Apr 20201585437412761
May 20202113901713
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