In DepthBiomedicine

Cancer DNA blood test gets real-world trial

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Science  01 May 2020:
Vol. 368, Issue 6490, pp. 461
DOI: 10.1126/science.368.6490.461

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Summary

Detecting many kinds of cancers early, with a simple blood test for DNA shed by tumor cells, is a seductive prospect. This week, a pioneering real-world study confirmed some of the promise. In the first trial of such a test in a large, general population of nearly 10,000 women not known to have cancer, an assay detected 26 tumors, researchers reported online in Science this week and at a virtual session of an American Association for Cancer Research meeting. But the study also produced a small but not insignificant number of alarming but false detections. Observers say the results are promising, but leave key questions unanswered.

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