Research Article

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

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Science  29 May 2020:
Vol. 368, Issue 6494, eaaz7548
DOI: 10.1126/science.aaz7548

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vol. 368 no. 6494

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History: 
  • Received for publication October 7, 2019
  • Accepted for publication April 3, 2020
  • .

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Author Information

  1. Zhiwei Zhou1,3,*,
  2. Huabin He2,3,*,
  3. Kun Wang3,
  4. Xuyan Shi3,
  5. Yupeng Wang1,3,
  6. Ya Su3,
  7. Yao Wang4,
  8. Da Li3,
  9. Wang Liu1,3,
  10. Yongliang Zhang5,
  11. Lianjun Shen5,
  12. Weidong Han4,
  13. Lin Shen6,
  14. Jingjin Ding3,7,
  15. Feng Shao1,3,7,8,
  1. 1Research Unit of Pyroptosis and Immunity, Chinese Academy of Medical Sciences and National Institute of Biological Sciences, Beijing, Beijing 102206, China.
  2. 2Peking University–Tsinghua University–National Institute of Biological Sciences Joint Graduate Program, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  3. 3National Institute of Biological Sciences, Beijing, Beijing 102206, China.
  4. 4Department of Molecular and Immunology and Department of Bio-therapeutics, Chinese PLA General Hospital, Beijing 100853, China.
  5. 5Gracell Biotechnologies, Shanghai 200233, China.
  6. 6Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing 100142, China.
  7. 7National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences (CAS), Beijing 100101, China.
  8. 8Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
  1. Corresponding author. Email: shaofeng{at}nibs.ac.cn
  1. * These authors contributed equally to this work.

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