19 June 2020
Vol 368, Issue 6497

About The Cover

Cover image expansion

COVER Upon infection, SARS-CoV-2 (blue) uses host machinery to produce polyproteins for replication. The viral main protease (yellow) plays a key role in polyprotein cleavage and thus is a potential drug target. Researchers have designed two antiviral compounds that inhibit activity of the main protease to prevent viral replication. Preclinical studies show that these compounds are promising therapeutic candidates. See page 1331.
Illustration: C. Bickel/Science; Data: PDB ID 6M0K (SARS-CoV-2 main protease)