Research Article

Exploring whole-genome duplicate gene retention with complex genetic interaction analysis

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Science  26 Jun 2020:
Vol. 368, Issue 6498, eaaz5667
DOI: 10.1126/science.aaz5667

Article Information

vol. 368 no. 6498

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  • Received for publication September 19, 2019
  • Accepted for publication May 6, 2020
  • .

Author Information

  1. Elena Kuzmin1,2,*,,
  2. Benjamin VanderSluis3,*,
  3. Alex N. Nguyen Ba4,5,,
  4. Wen Wang3,
  5. Elizabeth N. Koch3,
  6. Matej Usaj1,
  7. Anton Khmelinskii6,§,
  8. Mojca Mattiazzi Usaj1,
  9. Jolanda van Leeuwen1,,
  10. Oren Kraus1,2,
  11. Amy Tresenrider7,
  12. Michael Pryszlak1,2,
  13. Ming-Che Hu1,
  14. Brenda Varriano1,
  15. Michael Costanzo1,
  16. Michael Knop6,8,
  17. Alan Moses4,5,9,
  18. Chad L. Myers3,#,
  19. Brenda J. Andrews1,2,#,
  20. Charles Boone1,2,#
  1. 1Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
  2. 2Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.
  3. 3Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
  4. 4Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
  5. 5Center for Analysis of Evolution and Function, University of Toronto, Toronto, Ontario, Canada.
  6. 6Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany.
  7. 7Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
  8. 8Cell Morphogenesis and Signal Transduction, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  9. 9Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.
  1. #Corresponding author. Email: charlie.boone{at} (C.B.); brenda.andrews{at} (B.J.A.); chadm{at} (C.L.M.)
  1. * These authors contributed equally to this work.

  • Present address: Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.

  • Present address: Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.

  • § Present address: Institute of Molecular Biology, Mainz, Germany.

  • Present address: Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.


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