PerspectivePhysiology

Exercising your mind

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Science  10 Jul 2020:
Vol. 369, Issue 6500, pp. 144-145
DOI: 10.1126/science.abc8830

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Summary

Although the beneficial effects of exercise on the brain and cognition are generally accepted, the mechanisms by which physically active people remain mentally sharp later in life have been unclear. On page 167 of this issue, Horowitz et al. (1) demonstrate that the beneficial effects of exercise in mitigating brain aging can be conveyed from exercising mice to sedentary mice through plasma transfer. The authors also provide compelling evidence that the positive effects of exercise on brain aging are at least partially mediated through hepatic mechanisms and identify a promising target for further study.

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