Research Article

Human fetal microglia acquire homeostatic immune-sensing properties early in development

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Science  31 Jul 2020:
Vol. 369, Issue 6503, pp. 530-537
DOI: 10.1126/science.aba5906

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The development of microglia

Microglia are the brain's immune cells, and they play important roles in health and neurodegenerative disease. Kracht et al. performed single-cell analysis of human microglial gene expression and chromatin accessibility and compared the results with those of other studies of human and mice microglial development. By using in situ validation, these data identify fetal microglial subsets that appear to be distinct from adult human microglia, suggesting functional differences between the developing and mature brain.

Science, this issue p. 530

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