Research Article
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
- View ORCID ProfilePhilip J. M. Brouwer1,*,
- View ORCID ProfileTom G. Caniels1,*,
- View ORCID ProfileKarlijn van der Straten1,2,*,
- Jonne L. Snitselaar1,
- View ORCID ProfileYoann Aldon1,
- Sandhya Bangaru3,
- View ORCID ProfileJonathan L. Torres3,
- View ORCID ProfileNisreen M. A. Okba4,
- Mathieu Claireaux1,
- Gius Kerster1,
- View ORCID ProfileArthur E. H. Bentlage5,
- Marlies M. van Haaren1,
- View ORCID ProfileDenise Guerra1,
- Judith A. Burger1,
- Edith E. Schermer1,
- Kirsten D. Verheul1,
- Niels van der Velde6,
- View ORCID ProfileAlex van der Kooi6,
- View ORCID ProfileJelle van Schooten1,
- Mariëlle J. van Breemen1,
- Tom P. L. Bijl1,
- View ORCID ProfileKwinten Sliepen1,
- Aafke Aartse1,7,
- View ORCID ProfileRonald Derking1,
- Ilja Bontjer1,
- Neeltje A. Kootstra8,
- View ORCID ProfileW. Joost Wiersinga2,
- View ORCID ProfileGestur Vidarsson5,
- View ORCID ProfileBart L. Haagmans4,
- View ORCID ProfileAndrew B. Ward3,
- View ORCID ProfileGodelieve J. de Bree2,†,
- View ORCID ProfileRogier W. Sanders1,9,†,
- View ORCID ProfileMarit J. van Gils1,†
- 1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
- 2Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
- 3Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
- 4Department of Viroscience, Erasmus Medical Center, Rotterdam, 3015GD, Netherlands.
- 5Sanquin Research, Department of Experimental Immunohematology, Amsterdam, Netherlands and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1006AD Amsterdam, Netherlands.
- 6IBIS Technologies BV, 7521PR Enschede, Netherlands.
- 7Department of Virology, Biomedical Primate Research Centre, 2288GJ Rijswijk, Netherlands.
- 8Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
- 9Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.
- ↵†Corresponding author. Email: m.j.vangils{at}amsterdamumc.nl (M.J.v.G.); r.w.sanders{at}amsterdamumc.nl (R.W.S.); g.j.debree{at}amsterdamumc.nl (G.J.d.B.)
↵* These authors contributed equally to this work.
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Science 07 Aug 2020:
Vol. 369, Issue 6504, pp. 643-650
DOI: 10.1126/science.abc5902
Vol. 369, Issue 6504, pp. 643-650
DOI: 10.1126/science.abc5902
Philip J. M. Brouwer
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Tom G. Caniels
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Karlijn van der Straten
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
2Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Jonne L. Snitselaar
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Yoann Aldon
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Sandhya Bangaru
3Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Jonathan L. Torres
3Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Nisreen M. A. Okba
4Department of Viroscience, Erasmus Medical Center, Rotterdam, 3015GD, Netherlands.
Mathieu Claireaux
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Gius Kerster
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Arthur E. H. Bentlage
5Sanquin Research, Department of Experimental Immunohematology, Amsterdam, Netherlands and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1006AD Amsterdam, Netherlands.
Marlies M. van Haaren
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Denise Guerra
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Judith A. Burger
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Edith E. Schermer
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Kirsten D. Verheul
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Niels van der Velde
6IBIS Technologies BV, 7521PR Enschede, Netherlands.
Alex van der Kooi
6IBIS Technologies BV, 7521PR Enschede, Netherlands.
Jelle van Schooten
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Mariëlle J. van Breemen
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Tom P. L. Bijl
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Kwinten Sliepen
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Aafke Aartse
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
7Department of Virology, Biomedical Primate Research Centre, 2288GJ Rijswijk, Netherlands.
Ronald Derking
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Ilja Bontjer
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Neeltje A. Kootstra
8Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
W. Joost Wiersinga
2Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Gestur Vidarsson
5Sanquin Research, Department of Experimental Immunohematology, Amsterdam, Netherlands and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, 1006AD Amsterdam, Netherlands.
Bart L. Haagmans
4Department of Viroscience, Erasmus Medical Center, Rotterdam, 3015GD, Netherlands.
Andrew B. Ward
3Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Godelieve J. de Bree
2Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
Rogier W. Sanders
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
9Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA.
Marit J. van Gils
1Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, 1105AZ Amsterdam, Netherlands.
