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Type III interferons disrupt the lung epithelial barrier upon viral recognition

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Science  07 Aug 2020:
Vol. 369, Issue 6504, pp. 706-712
DOI: 10.1126/science.abc3545

Article Information

vol. 369 no. 6504 706-712

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History: 
  • Received for publication April 21, 2020
  • Accepted for publication June 8, 2020
  • .

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Author Information

  1. Achille Broggi1,*,
  2. Sreya Ghosh1,*,
  3. Benedetta Sposito1,2,*,
  4. Roberto Spreafico3,,
  5. Fabio Balzarini1,2,
  6. Antonino Lo Cascio1,2,
  7. Nicola Clementi4,
  8. Maria De Santis5,
  9. Nicasio Mancini4,6,
  10. Francesca Granucci2,7,
  11. Ivan Zanoni1,2,8,
  1. 1Harvard Medical School, Boston Children’s Hospital, Division of Immunology, Boston, MA, USA.
  2. 2Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
  3. 3Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, CA, USA.
  4. 4Laboratory of Medical Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy.
  5. 5Department of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Italy.
  6. 6IRCCS San Raffaele Hospital, Milan, Italy.
  7. 7National Institute of Molecular Genetics (INGM) “Romeo ed Enrica Invernizzi,” Milan, Italy.
  8. 8Harvard Medical School, Boston Children’s Hospital, Division of Gastroenterology, Boston, MA, USA.
  1. Corresponding author. Email: ivan.zanoni{at}childrens.harvard.edu
  1. * These authors contributed equally to this work.

  • Present address: Vir Biotechnology, San Francisco, CA, USA.

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