Research Article

The proteasome controls ESCRT-III–mediated cell division in an archaeon

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Science  07 Aug 2020:
Vol. 369, Issue 6504, eaaz2532
DOI: 10.1126/science.aaz2532

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Proteasomal control of division in Archaea

In eukaryotes, proteasome-mediated degradation of cell cycle factors triggers mitotic exit, DNA segregation, and cytokinesis, a process that culminates in abscission dependent on the protein ESCRT-III. By studying cell division in an archaeal relative of eukaryotes, Tarrason Risa et al. identified a role for the proteasome in triggering cytokinesis by an archaeal ESCRT-III homolog. Cell division in this archaeon was driven by stepwise remodeling of a composite ESCRT-III–based division ring, where rapid proteasome-mediated degradation of one ESCRT-III subunit triggered the constriction of the remaining ESCRT-III–based copolymer. These data strengthen the case for the eukaryotic cell division machinery having its origins in Archaea.

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