Contents
04 September 2020
Vol 369, Issue 6508
Vol 369, Issue 6508
Special Issue
Democracy in the Balance
Introduction to special issue
Policy Forum
- Racial authoritarianism in U.S. democracy
One segment of the population experiences different rules and differential citizenship.
- Human-centered redistricting automation in the age of AI
Human-machine collaboration and transparency are key
Perspective
- Campaigns influence election outcomes less than you think
Campaigns have small effects but are built to win close races
Reviews
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Can Europe tame the pandemic's next wave?
Countries seek new strategies as coronavirus cases are rising again across the continent
- Bill threatens key Brazilian universities
Proposal to strip São Paulo institutions of reserve funds draws fierce opposition
- Malaria fighters' latest chemical weapon may not last long
Clothianidin-resistant mosquitoes already seen in Cameroon
- An ecosystem goes topsy-turvy as a tiny fish takes over
Predator-prey reversal has dramatically altered the underwater ecosystem along the Baltic Coast archipelago
- Cannabis research data reveals a focus on harms of the drug
Funding for therapies grows slowly, new analysis finds
Feature
- The carbon vault
Industrial waste can combat climate change by turning carbon dioxide into stone
Working Life
Letters
Books et al.
- The Stepford wife gets smart
A pair of digital scholars confront the troubling implications of feminized household management technologies
- Biology's brave new world
The promise and perils of synthetic biology take center stage in a fast-paced new series
Perspectives
- High-precision molecular measurement
Spectroscopy of hydrogen deuteride ions provides the proton-to-electron mass ratio
- Soil age alters the global silicon cycle
As rocks undergo prolonged chemical weathering, plants become more important for supplying bioavailable silicon
- Dynamics of death by heat
Time at high temperature modulates fly mortality in nature
- Sexual dimorphism in body clocks
Sexual dimorphism in chronobiology has implications for the health of our 24-hour society
- Can proteins be truly designed sans function?
A new unit of local protein structure can aid in the de novo design of ligand-binding proteins
- A molecular trap against COVID-19
Structure-function studies reveal a new receptor decoy to block virus entry
Research Articles
- Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons
A group of neurons in the basal forebrain mediates increased sleep pressure during wakefulness in mice.
- Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates
Comparison of two related but evolutionarily distant fish species reveals regulatory elements involved in tissue regeneration.
- Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation
Near-complete reconstitution of the yeast autophagy machinery defines Atg9 vesicles as nucleators of autophagosomes.
- Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
Immune responses of COVID-19 patients are cataloged and compared with those of healthy individuals.
- Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans
Immune responses of COVID-19 patients are cataloged and compared with those of healthy individuals.
- Structure of a human 48S translational initiation complex
A cryo–electron microscopy structure provides insight into how the translational initiation complex scans mRNA to find the start site.
- A defined structural unit enables de novo design of small-molecule–binding proteins
An innovative representation of protein–chemical-group interactions enables design of proteins that bind the blood-thinning drug apixaban.
expression of concern
Reports
- A triple-star system with a misaligned and warped circumstellar disk shaped by disk tearing
The circumstellar disk in a nearby triple-star system has complex structures produced by disk tearing.
- Proton-electron mass ratio from laser spectroscopy of HD+ at the part-per-trillion level
Rovibrational spectra of hydrogen deuteride molecular ions in a linear Paul trap refine the precision of a fundamental ratio.
- Predicting temperature mortality and selection in natural Drosophila populations
Accounting for cumulative effects of warming improves mortality predictions in wild fruit flies.
- Plants sustain the terrestrial silicon cycle during ecosystem retrogression
Plants retain and accumulate silicon when soil reserves are depleted, thereby sustaining silicon cycling.
- Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
SARS-CoV-2 protein Nsp1 suppresses host translation and immune responses by blocking the ribosomal mRNA entry tunnel.
- Evolution and epidemic spread of SARS-CoV-2 in Brazil
Large, highly connected urban centers drove virus spread across Brazil after introduction from Europe.
- Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
A variant of ACE2 based on deep mutagenesis far outcompetes the natural receptor in binding the SARS-CoV-2 spike protein.
Erratum
About The Cover
COVER Democracy is a global phenomenon, but so are the myriad challenges that threaten to throw it off balance. Violence and repression, polarization and disinformation, diversity and inequality—all highlight the need for social and behavioral scientists to understand how democracy might adapt and even thrive in the face of such obstacles. See page 1174. Illustration: Davide Bonazzi/salzmanart
