The hepatocyte clock and feeding control chronophysiology of multiple liver cell types

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Science  11 Sep 2020:
Vol. 369, Issue 6509, pp. 1388-1394
DOI: 10.1126/science.aba8984

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Keeping rhythm requires communication

In mammals, daily cycles in physiology require the synchronized activity of circadian clocks in peripheral organs such as the liver, a hub of metabolism. Guan et al. generated mice with hepatocytes that lack two transcriptional repressors known to be essential for clock function. This experimental manipulation unexpectedly disrupted rhythmic gene expression and metabolism not only in hepatocytes but also in other liver cell types. Feeding behavior also coregulated circadian rhythms in multiple liver cell types. Cell-cell communication thus appears to be important in maintaining the robustness of peripheral circadian clocks.

Science, this issue p. 1388

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