Research Article
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy
- View ORCID ProfileHongjing Gu1,*,
- View ORCID ProfileQi Chen1,*,
- View ORCID ProfileGuan Yang2,*,
- View ORCID ProfileLei He1,*,
- View ORCID ProfileHang Fan1,*,
- View ORCID ProfileYong-Qiang Deng1,*,
- Yanxiao Wang2,
- Yue Teng1,
- View ORCID ProfileZhongpeng Zhao1,
- View ORCID ProfileYujun Cui1,
- Yuchang Li1,
- View ORCID ProfileXiao-Feng Li1,
- View ORCID ProfileJiangfan Li1,
- View ORCID ProfileNa-Na Zhang1,
- View ORCID ProfileXiaolan Yang1,
- Shaolong Chen1,
- Yan Guo1,
- View ORCID ProfileGuangyu Zhao1,
- View ORCID ProfileXiliang Wang1,
- De-Yan Luo1,
- Hui Wang1,
- View ORCID ProfileXiao Yang2,
- Yan Li3,
- Gencheng Han3,
- Yuxian He4,
- Xiaojun Zhou5,
- Shusheng Geng6,
- Xiaoli Sheng6,
- View ORCID ProfileShibo Jiang7,†,‡,
- View ORCID ProfileShihui Sun1,†,‡,
- View ORCID ProfileCheng-Feng Qin1,†,‡,
- View ORCID ProfileYusen Zhou1,‡,§
- 1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
- 2State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
- 3Institute of Military Cognition and Brain Sciences, Beijing 100850, China.
- 4Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
- 5Laboratory Animal Center, Academy of Military Medical Sciences, Beijing 100071, China.
- 6Beijing JOINN Biologics Co., Beijing 100176, China.
- 7Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
- ↵†Corresponding author. Email: shibojiang{at}fudan.edu.cn (S.J.); sunsh01{at}163.com (S.S.); qincf{at}bmi.ac.cn (C.-F.Q.)
↵‡ These authors contributed equally to this work.
See allHide authors and affiliations
Science 25 Sep 2020:
Vol. 369, Issue 6511, pp. 1603-1607
DOI: 10.1126/science.abc4730
Vol. 369, Issue 6511, pp. 1603-1607
DOI: 10.1126/science.abc4730
Hongjing Gu
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Qi Chen
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Guan Yang
2State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Lei He
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Hang Fan
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Yong-Qiang Deng
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Yanxiao Wang
2State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Yue Teng
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Zhongpeng Zhao
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Yujun Cui
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Yuchang Li
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Xiao-Feng Li
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Jiangfan Li
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Na-Na Zhang
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Xiaolan Yang
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Shaolong Chen
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Yan Guo
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Guangyu Zhao
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Xiliang Wang
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
De-Yan Luo
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Hui Wang
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Xiao Yang
2State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Yan Li
3Institute of Military Cognition and Brain Sciences, Beijing 100850, China.
Gencheng Han
3Institute of Military Cognition and Brain Sciences, Beijing 100850, China.
Yuxian He
4Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Xiaojun Zhou
5Laboratory Animal Center, Academy of Military Medical Sciences, Beijing 100071, China.
Shusheng Geng
6Beijing JOINN Biologics Co., Beijing 100176, China.
Xiaoli Sheng
6Beijing JOINN Biologics Co., Beijing 100176, China.
Shibo Jiang
7Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Shihui Sun
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Cheng-Feng Qin
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Yusen Zhou
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
