PerspectiveLandmark: Neurodegeneration

Shifts and drifts in prion science

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Science  02 Oct 2020:
Vol. 370, Issue 6512, pp. 32-34
DOI: 10.1126/science.abb8577

Figures

  • Three centuries of prion science

    The timeline shows key prion-related discoveries. In 1982, Prusiner suggested that the prion protein (PrP) is the infectious cause of spongiform encephalopathies, including Kuru, scrapie, and Creutzfeldt-Jakob disease (CJD). These insights have had implications for many neurodegenerative diseases involving prionoids, but many questions still remain unanswered.

    GRAPHIC: MELISSA THOMAS BAUM/SCIENCE; (IMAGES, LEFT TO RIGHT) K. FRONTZEK; U. S. HERMANN ET AL., SCI. TRANSL. MED. 7, 299RA123 (2015); G. SPAGNOLLI, ADAPTED FROM (12)

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