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Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

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Science  16 Oct 2020:
Vol. 370, Issue 6514, pp. 360-364
DOI: 10.1126/science.abb4808

Article Information

vol. 370 no. 6514 360-364

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 26, 2020
  • Accepted for publication August 25, 2020
  • .

Author Information

  1. Stephanie M. Bester1,*,
  2. Guochao Wei1,*,
  3. Haiyan Zhao2,*,
  4. Daniel Adu-Ampratwum3,
  5. Naseer Iqbal2,
  6. Valentine V. Courouble4,
  7. Ashwanth C. Francis5,
  8. Arun S. Annamalai1,
  9. Parmit K. Singh6,7,
  10. Nikoloz Shkriabai1,
  11. Peter Van Blerkom2,
  12. James Morrison1,
  13. Eric M. Poeschla1,
  14. Alan N. Engelman6,7,
  15. Gregory B. Melikyan5,
  16. Patrick R. Griffin4,
  17. James R. Fuchs3,
  18. Francisco J. Asturias2,,
  19. Mamuka Kvaratskhelia1,
  1. 1Division of Infectious Diseases, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  2. 2Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO 80045, USA.
  3. 3Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
  4. 4Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.
  5. 5Department of Pediatrics, Infectious Diseases, Emory University, Atlanta, GA 30322, USA.
  6. 6Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  7. 7Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  1. Corresponding author. Email: mamuka.kvaratskhelia{at}cuanschutz.edu (M.K.); francisco.asturias{at}cuanschutz.edu (F.J.A.)
  1. * These authors contributed equally to this work.

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