Report
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
- View ORCID ProfileLudovico Cantuti-Castelvetri1,2,*,
- View ORCID ProfileRavi Ojha3,*,
- View ORCID ProfileLiliana D. Pedro1,2,*,
- View ORCID ProfileMinou Djannatian1,2,*,
- View ORCID ProfileJonas Franz4,5,6,*,
- View ORCID ProfileSuvi Kuivanen7,*,
- View ORCID ProfileFranziska van der Meer4,
- Katri Kallio3,
- View ORCID ProfileTuğberk Kaya1,2,8,
- View ORCID ProfileMaria Anastasina3,9,
- Teemu Smura7,
- Lev Levanov7,
- View ORCID ProfileLeonora Szirovicza7,
- View ORCID ProfileAllan Tobi10,
- Hannimari Kallio-Kokko11,
- View ORCID ProfilePamela Österlund12,
- View ORCID ProfileMerja Joensuu13,
- View ORCID ProfileFrédéric A. Meunier13,
- View ORCID ProfileSarah J. Butcher3,9,
- Martin Sebastian Winkler14,
- Brit Mollenhauer15,16,
- Ari Helenius17,
- View ORCID ProfileOzgun Gokce8,
- View ORCID ProfileTambet Teesalu3,19,20,
- View ORCID ProfileJussi Hepojoki5,21,
- View ORCID ProfileOlli Vapalahti7,11,22,
- View ORCID ProfileChristine Stadelmann4,
- View ORCID ProfileGiuseppe Balistreri3,18,†,
- View ORCID ProfileMikael Simons1,2,23,†
- 1Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
- 2German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
- 3Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland.
- 4Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.
- 5Campus Institute for Dynamics of Biological Networks, University of Göttingen, Göttingen, Germany.
- 6Max Planck Institute for Experimental Medicine, Göttingen, Germany.
- 7Department of Virology, Medicum, University of Helsinki, Helsinki, Finland.
- 8Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
- 9Helsinki Institute of Life Sciences–Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
- 10Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
- 11Department of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
- 12Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
- 13Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
- 14Department of Anesthesiology and Intensive Care Medicine, University Medical Center Göttingen, Göttingen, Germany.
- 15Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
- 16Paracelsus-Elena-Klinik Kassel, Kassel, Germany.
- 17Institute of Biochemistry, ETH Zürich, Zürich, Switzerland.
- 18The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
- 19Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
- 20Center for Nanomedicine and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.
- 21Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.
- 22Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
- 23Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
- ↵†Corresponding author. Email: giuseppe.balistreri{at}helsinki.fi (G.B.); mikael.simons{at}dzne.de (M.S.)
↵* These authors contributed equally to this work.
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Science 13 Nov 2020:
Vol. 370, Issue 6518, pp. 856-860
DOI: 10.1126/science.abd2985
Vol. 370, Issue 6518, pp. 856-860
DOI: 10.1126/science.abd2985
Ludovico Cantuti-Castelvetri
1Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
2German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Ravi Ojha
3Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland.
Liliana D. Pedro
1Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
2German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Minou Djannatian
1Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
2German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Jonas Franz
4Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.
5Campus Institute for Dynamics of Biological Networks, University of Göttingen, Göttingen, Germany.
6Max Planck Institute for Experimental Medicine, Göttingen, Germany.
Suvi Kuivanen
7Department of Virology, Medicum, University of Helsinki, Helsinki, Finland.
Franziska van der Meer
4Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.
Katri Kallio
3Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland.
Tuğberk Kaya
1Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
2German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
8Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Maria Anastasina
3Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland.
9Helsinki Institute of Life Sciences–Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
Teemu Smura
7Department of Virology, Medicum, University of Helsinki, Helsinki, Finland.
Lev Levanov
7Department of Virology, Medicum, University of Helsinki, Helsinki, Finland.
Leonora Szirovicza
7Department of Virology, Medicum, University of Helsinki, Helsinki, Finland.
Allan Tobi
10Laboratory of Cancer Biology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Hannimari Kallio-Kokko
11Department of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Pamela Österlund
12Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
Merja Joensuu
13Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Frédéric A. Meunier
13Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Sarah J. Butcher
3Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland.
9Helsinki Institute of Life Sciences–Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
Martin Sebastian Winkler
14Department of Anesthesiology and Intensive Care Medicine, University Medical Center Göttingen, Göttingen, Germany.
Brit Mollenhauer
15Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
16Paracelsus-Elena-Klinik Kassel, Kassel, Germany.
Ari Helenius
17Institute of Biochemistry, ETH Zürich, Zürich, Switzerland.
Ozgun Gokce
8Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Tambet Teesalu
3Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland.
19Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
20Center for Nanomedicine and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA, USA.
Jussi Hepojoki
5Campus Institute for Dynamics of Biological Networks, University of Göttingen, Göttingen, Germany.
21Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.
Olli Vapalahti
7Department of Virology, Medicum, University of Helsinki, Helsinki, Finland.
11Department of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
22Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.
Christine Stadelmann
4Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.
Giuseppe Balistreri
3Faculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Program, University of Helsinki, Helsinki, Finland.
18The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Mikael Simons
1Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
2German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
23Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
