Report

A marine microbiome antifungal targets urgent-threat drug-resistant fungi

See allHide authors and affiliations

Science  20 Nov 2020:
Vol. 370, Issue 6519, pp. 974-978
DOI: 10.1126/science.abd6919

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Prospecting for antifungal molecules

Marine bacteria produce a plethora of natural products that often have unusual chemical structures and corresponding reactivity, which sometimes translate into a valuable biological function. Zhang et al. used a metabolomic screen to zero in on microbial strains from the microbiome of a sea squirt that produces a high diversity of chemical structures. They then screened these molecules for inhibition of fungi (see the Perspective by Cowen). A polycyclic molecule dubbed turbinmicin possessed potent antifungal activity against the multidrug-resistant fungal pathogens Candida auris and Aspergillus fumigatus. Preliminary mechanism-of-action and mouse toxicity studies suggest that this molecule works though a fungus-specific pathway and is well tolerated at therapeutic doses.

Science, this issue p. 974; see also p. 906

View Full Text

Stay Connected to Science