From the AAAS Office of PublishingBusiness Office Feature

Technology Feature | Can patients' gut microbes help fight cancer?

See allHide authors and affiliations

Science  20 Nov 2020:
Vol. 370, Issue 6519, pp. 997-1000
DOI: 10.1126/science.370.6519.997


A healthy gut microbiome seems to be required for immuno-oncology therapies designed to turn up the body's immune response to attack tumors. Researchers have many “black boxes” to fill in on how gut microbes directly or indirectly influence the T cells unleashed by immune checkpoint inhibitor therapies. But several groups are betting that microbiome-based therapies can help more patients respond to immunotherapies and become one of the biggest breakthroughs in cancer treatment in decades.

Stay Connected to Science