Research Article

Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau

See allHide authors and affiliations

Science  20 Nov 2020:
Vol. 370, Issue 6519, eaay8826
DOI: 10.1126/science.aay8826

Article Information

vol. 370 no. 6519

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 25, 2019
  • Resubmitted July 16, 2020
  • Accepted for publication September 17, 2020
  • .

Article Versions

Author Information

  1. Nabil F. Darwich1,*,
  2. Jessica M. Phan1,*,
  3. Boram Kim1,
  4. EunRan Suh2,
  5. John D. Papatriantafyllou3,
  6. Lakshmi Changolkar2,
  7. Aivi T. Nguyen1,
  8. Caroline M. O’Rourke1,
  9. Zhuohao He2,,
  10. Sílvia Porta2,
  11. Garrett S. Gibbons2,
  12. Kelvin C. Luk2,
  13. Sokratis G. Papageorgiou4,
  14. Murray Grossman5,
  15. Lauren Massimo5,
  16. David J. Irwin5,
  17. Corey T. McMillan5,
  18. Ilya M. Nasrallah6,
  19. Camilo Toro7,
  20. Geoffrey K. Aguirre5,
  21. Vivianna M. Van Deerlin2,
  22. Edward B. Lee1,
  1. 1Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
  2. 2Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
  3. 3Medical Center of Athens, Memory Disorders Clinic and Day Care Center for Third Age “IASIS,” Athens, Greece.
  4. 4First University Department of Neurology, Eginiteio University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  5. 5Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
  6. 6Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, PA, USA.
  7. 7NIH Undiagnosed Diseases Program, National Human Genome Research Institute, MD, USA.
  1. Corresponding author. Email: edward.lee{at}pennmedicine.upenn.edu
  1. * These authors contributed equally to this work.

  • Present address: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.

Altmetric

Article usage

Article usage: September 2020 to July 2021

AbstractFullPdf
Sep 2020021
Oct 202092673220989
Nov 202052481774706
Dec 2020804519320
Jan 2021637283171
Feb 2021471160102
Mar 2021432167103
Apr 202154712793
May 202145510053
Jun 20213169734
Jul 20212098457

Stay Connected to Science