PerspectiveGenomics

Sequencing perturbed cortex development

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Science  27 Nov 2020:
Vol. 370, Issue 6520, pp. 1038-1039
DOI: 10.1126/science.abf3661

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Summary

Tissues are complex and contain a diverse compendium of cell types and states. Genetic disruptions can affect any one or all of these cells and, in doing so, sometimes give rise to disease. There are thousands of genes associated with human disease, and studying the effects of genetic disruption across all cell types within mammalian tissues remains difficult. Perturbations with single-cell sequencing readouts have promised extraordinary insight through increased throughput and enhanced resolution. On page 1057 of this issue, Jin et al. (1) combine in vivo genetic disruptions of genes associated with the risk of developing autism spectrum disorder (ASD) or neurodevelopmental delay (ND) with single-cell transcriptome sequencing to explore effects across diverse cells in the developing mouse cortex.

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