You are currently viewing the summary.
View Full TextLog in to view the full text
AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.
More options
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
Summary
Tissues are complex and contain a diverse compendium of cell types and states. Genetic disruptions can affect any one or all of these cells and, in doing so, sometimes give rise to disease. There are thousands of genes associated with human disease, and studying the effects of genetic disruption across all cell types within mammalian tissues remains difficult. Perturbations with single-cell sequencing readouts have promised extraordinary insight through increased throughput and enhanced resolution. On page 1057 of this issue, Jin et al. (1) combine in vivo genetic disruptions of genes associated with the risk of developing autism spectrum disorder (ASD) or neurodevelopmental delay (ND) with single-cell transcriptome sequencing to explore effects across diverse cells in the developing mouse cortex.
This is an article distributed under the terms of the Science Journals Default License.
