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Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
- View ORCID ProfileKevin W. Ng1*,
- View ORCID ProfileNikhil Faulkner1*,
- View ORCID ProfileGeorgina H. Cornish1*,
- View ORCID ProfileAnnachiara Rosa2*,
- Ruth Harvey3,
- View ORCID ProfileSaira Hussain3,
- Rachel Ulferts9,
- View ORCID ProfileChristopher Earl4,
- View ORCID ProfileAntoni G. Wrobel5,
- View ORCID ProfileDonald J. Benton5,
- View ORCID ProfileChloe Roustan6,
- William Bolland1,
- Rachael Thompson1,
- View ORCID ProfileAna Agua-Doce7,
- View ORCID ProfilePhilip Hobson7,
- Judith Heaney13,
- View ORCID ProfileHannah Rickman13,
- Stavroula Paraskevopoulou13,
- View ORCID ProfileCatherine F. Houlihan13,14,
- View ORCID ProfileKirsty Thomson13,
- Emilie Sanchez13,
- View ORCID ProfileGee Yen Shin13,
- View ORCID ProfileMoira J. Spyer13,15,
- View ORCID ProfileDhira Joshi8,
- View ORCID ProfileNicola O’Reilly8,
- View ORCID ProfilePhilip A. Walker6,
- View ORCID ProfileSvend Kjaer6,
- Andrew Riddell7,
- View ORCID ProfileCatherine Moore16,
- View ORCID ProfileBethany R. Jebson17,19,
- View ORCID ProfileMeredyth Wilkinson17,19,
- Lucy R. Marshall17,19,
- View ORCID ProfileElizabeth C. Rosser17,18,
- View ORCID ProfileAnna Radziszewska17,18,
- View ORCID ProfileHannah Peckham17,18,
- View ORCID ProfileCoziana Ciurtin17,18,
- Lucy R. Wedderburn17,19,
- View ORCID ProfileRupert Beale9,
- View ORCID ProfileCharles Swanton10,
- Sonia Gandhi11,
- View ORCID ProfileBrigitta Stockinger12,
- View ORCID ProfileJohn McCauley3,
- View ORCID ProfileSteve J. Gamblin5,
- View ORCID ProfileLaura E. McCoy14,†,
- View ORCID ProfilePeter Cherepanov2,†,
- View ORCID ProfileEleni Nastouli13,15,†,
- View ORCID ProfileGeorge Kassiotis1,20,†
- 1Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK.
- 2Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
- 3Worldwide Influenza Centre, The Francis Crick Institute, London NW1 1AT, UK.
- 4Signalling and Structural Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
- 5Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
- 6Structural Biology STP, The Francis Crick Institute, London NW1 1AT, UK.
- 7Flow Cytometry STP, The Francis Crick Institute, London NW1 1AT, UK.
- 8Peptide Chemistry, The Francis Crick Institute, London NW1 1AT, UK.
- 9Cell Biology of Infection Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
- 10Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
- 11Neurodegeneration Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
- 12AhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
- 13University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.
- 14Division of Infection and Immunity, University College London (UCL), London WC1E 6BT, UK.
- 15Department of Population, Policy and Practice, Great Ormond Street Institute for Child Health (ICH), UCL, London WC1N 1EH, UK.
- 16Public Health Wales, University Hospital of Wales, Cardiff CF14 4XW, UK.
- 17Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, Great Ormond Street Hospital (GOSH), London WC1N 3JH, UK.
- 18Centre for Rheumatology Research, Division of Medicine, UCL, London, WC1E 6BT, UK.
- 19UCL Great Ormond Street Institute for Child Health (ICH), UCL, London WC1N 1EH, UK.
- 20Department of Medicine, Faculty of Medicine, Imperial College London, London W2 1PG, UK.
- ↵†Corresponding author. Email: george.kassiotis{at}crick.ac.uk (G.K.); e.nastouli{at}ucl.ac.uk (E.N.); peter.cherepanov{at}crick.ac.uk (P.C.); l.mccoy{at}ucl.ac.uk (L.E.M.)
↵* These authors contributed equally to this work.
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Science 11 Dec 2020:
Vol. 370, Issue 6522, pp. 1339-1343
DOI: 10.1126/science.abe1107
Vol. 370, Issue 6522, pp. 1339-1343
DOI: 10.1126/science.abe1107
Kevin W. Ng
1Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK.
Nikhil Faulkner
1Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK.
Georgina H. Cornish
1Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK.
Annachiara Rosa
2Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Ruth Harvey
3Worldwide Influenza Centre, The Francis Crick Institute, London NW1 1AT, UK.
Saira Hussain
3Worldwide Influenza Centre, The Francis Crick Institute, London NW1 1AT, UK.
Rachel Ulferts
9Cell Biology of Infection Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Christopher Earl
4Signalling and Structural Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Antoni G. Wrobel
5Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Donald J. Benton
5Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Chloe Roustan
6Structural Biology STP, The Francis Crick Institute, London NW1 1AT, UK.
William Bolland
1Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK.
Rachael Thompson
1Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK.
Ana Agua-Doce
7Flow Cytometry STP, The Francis Crick Institute, London NW1 1AT, UK.
Philip Hobson
7Flow Cytometry STP, The Francis Crick Institute, London NW1 1AT, UK.
Judith Heaney
13University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.
Hannah Rickman
13University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.
Stavroula Paraskevopoulou
13University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.
Catherine F. Houlihan
13University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.
14Division of Infection and Immunity, University College London (UCL), London WC1E 6BT, UK.
Kirsty Thomson
13University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.
Emilie Sanchez
13University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.
Gee Yen Shin
13University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.
Moira J. Spyer
13University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.
15Department of Population, Policy and Practice, Great Ormond Street Institute for Child Health (ICH), UCL, London WC1N 1EH, UK.
Dhira Joshi
8Peptide Chemistry, The Francis Crick Institute, London NW1 1AT, UK.
Nicola O’Reilly
8Peptide Chemistry, The Francis Crick Institute, London NW1 1AT, UK.
Philip A. Walker
6Structural Biology STP, The Francis Crick Institute, London NW1 1AT, UK.
Svend Kjaer
6Structural Biology STP, The Francis Crick Institute, London NW1 1AT, UK.
Andrew Riddell
7Flow Cytometry STP, The Francis Crick Institute, London NW1 1AT, UK.
Catherine Moore
16Public Health Wales, University Hospital of Wales, Cardiff CF14 4XW, UK.
Bethany R. Jebson
17Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, Great Ormond Street Hospital (GOSH), London WC1N 3JH, UK.
19UCL Great Ormond Street Institute for Child Health (ICH), UCL, London WC1N 1EH, UK.
Meredyth Wilkinson
17Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, Great Ormond Street Hospital (GOSH), London WC1N 3JH, UK.
19UCL Great Ormond Street Institute for Child Health (ICH), UCL, London WC1N 1EH, UK.
Lucy R. Marshall
17Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, Great Ormond Street Hospital (GOSH), London WC1N 3JH, UK.
19UCL Great Ormond Street Institute for Child Health (ICH), UCL, London WC1N 1EH, UK.
Elizabeth C. Rosser
17Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, Great Ormond Street Hospital (GOSH), London WC1N 3JH, UK.
18Centre for Rheumatology Research, Division of Medicine, UCL, London, WC1E 6BT, UK.
Anna Radziszewska
17Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, Great Ormond Street Hospital (GOSH), London WC1N 3JH, UK.
18Centre for Rheumatology Research, Division of Medicine, UCL, London, WC1E 6BT, UK.
Hannah Peckham
17Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, Great Ormond Street Hospital (GOSH), London WC1N 3JH, UK.
18Centre for Rheumatology Research, Division of Medicine, UCL, London, WC1E 6BT, UK.
Coziana Ciurtin
17Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, Great Ormond Street Hospital (GOSH), London WC1N 3JH, UK.
18Centre for Rheumatology Research, Division of Medicine, UCL, London, WC1E 6BT, UK.
Lucy R. Wedderburn
17Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, Great Ormond Street Hospital (GOSH), London WC1N 3JH, UK.
19UCL Great Ormond Street Institute for Child Health (ICH), UCL, London WC1N 1EH, UK.
Rupert Beale
9Cell Biology of Infection Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Charles Swanton
10Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Sonia Gandhi
11Neurodegeneration Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Brigitta Stockinger
12AhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
John McCauley
3Worldwide Influenza Centre, The Francis Crick Institute, London NW1 1AT, UK.
Steve J. Gamblin
5Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Laura E. McCoy
14Division of Infection and Immunity, University College London (UCL), London WC1E 6BT, UK.
Peter Cherepanov
2Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Eleni Nastouli
13University College London Hospitals (UCLH) NHS Trust, London NW1 2BU, UK.
15Department of Population, Policy and Practice, Great Ormond Street Institute for Child Health (ICH), UCL, London WC1N 1EH, UK.
George Kassiotis
1Retroviral Immunology, The Francis Crick Institute, London NW1 1AT, UK.
20Department of Medicine, Faculty of Medicine, Imperial College London, London W2 1PG, UK.
