In DepthCOVID-19

People with Down syndrome face high risk from coronavirus

See allHide authors and affiliations

Science  18 Dec 2020:
Vol. 370, Issue 6523, pp. 1384-1385
DOI: 10.1126/science.370.6523.1384

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. eLetters are not edited, proofread, or indexed.  Please read our Terms of Service before submitting your own eLetter.

Compose eLetter

Plain text

  • Plain text
    No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g.
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

  • RE: Covid-19, Down's Syndrome, and DHEA

    It is my hypothesis that Down's syndrome and Covid-19 infection and subsequent pathology are both caused by low dehydroepiandrosterone (DHEA). DHEA has already been demonstrated to protect against other viruses: "In this study it was shown that DHEA protects mice against WNV, SVNI and SFV lethal infection." (
    Arch Virol. 1991;120(3-4):263-71. doi: 10.1007/BF01310481.) I have submitted explanations of low DHEA regarding Covid-19 infection and Down's syndrome to numerous researchers and received no response. It is disconcerting that a possible basis of treatment of these may be treated with DHEA is being ignored.

    Competing Interests: None declared.

Stay Connected to Science