Report
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
- View ORCID ProfileYixuan J. Hou1,*,
- View ORCID ProfileShiho Chiba2,*,
- View ORCID ProfilePeter Halfmann2,
- View ORCID ProfileCamille Ehre3,
- Makoto Kuroda2,
- View ORCID ProfileKenneth H. Dinnon III4,
- View ORCID ProfileSarah R. Leist1,
- View ORCID ProfileAlexandra Schäfer1,
- View ORCID ProfileNoriko Nakajima5,
- Kenta Takahashi5,
- View ORCID ProfileRhianna E. Lee3,
- View ORCID ProfileTeresa M. Mascenik3,
- View ORCID ProfileRachel Graham1,
- View ORCID ProfileCaitlin E. Edwards1,
- View ORCID ProfileLongping V. Tse1,
- View ORCID ProfileKenichi Okuda3,
- View ORCID ProfileAlena J. Markmann6,
- View ORCID ProfileLuther Bartelt6,
- View ORCID ProfileAravinda de Silva4,
- View ORCID ProfileDavid M. Margolis1,4,6,
- Richard C. Boucher3,
- View ORCID ProfileScott H. Randell3,
- View ORCID ProfileTadaki Suzuki5,
- View ORCID ProfileLisa E. Gralinski1,
- View ORCID ProfileYoshihiro Kawaoka2,7,†,
- View ORCID ProfileRalph S. Baric1,4,†
- 1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 2Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
- 3Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 5Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
- 6Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 7Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
- ↵†Corresponding author. Email: yoshihiro.kawaoka{at}wisc.edu (Y.K.); rbaric{at}email.unc.edu (R.S.B.)
↵* These authors contributed equally to this work.
See allHide authors and affiliations
Science 18 Dec 2020:
Vol. 370, Issue 6523, pp. 1464-1468
DOI: 10.1126/science.abe8499
Vol. 370, Issue 6523, pp. 1464-1468
DOI: 10.1126/science.abe8499
Yixuan J. Hou
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shiho Chiba
2Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
Peter Halfmann
2Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
Camille Ehre
3Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Makoto Kuroda
2Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
Kenneth H. Dinnon III
4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sarah R. Leist
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alexandra Schäfer
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Noriko Nakajima
5Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Kenta Takahashi
5Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Rhianna E. Lee
3Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Teresa M. Mascenik
3Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Rachel Graham
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Caitlin E. Edwards
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Longping V. Tse
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kenichi Okuda
3Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alena J. Markmann
6Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Luther Bartelt
6Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Aravinda de Silva
4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
David M. Margolis
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
6Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Richard C. Boucher
3Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Scott H. Randell
3Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Tadaki Suzuki
5Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Lisa E. Gralinski
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yoshihiro Kawaoka
2Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
7Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Ralph S. Baric
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
