Report

A broadly protective antibody that targets the flavivirus NS1 protein

See allHide authors and affiliations

Science  08 Jan 2021:
Vol. 371, Issue 6525, pp. 190-194
DOI: 10.1126/science.abb9425

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Two antibodies against flaviviruses

Flaviviruses are a group of RNA viruses that include the human pathogens dengue virus, Zika virus, and West Nile virus. The envelope protein (E) on the virus surface has been the target of vaccine development, but problems have arisen with antibodies against E, leading to enhanced infection. Now, Modhiran et al. and Biering et al. describe two different antibodies that bind to the flavivirus NS1 protein and prevent it from disrupting epithelial cells, which is associated with severe disease. Both antibodies cross-react with multiple flavivirus NS1 proteins. The antibodies reduce viremia and increase survival in mouse models of flavivirus disease. Both papers include structures of NS1 bound to an antibody, which give insight into the protective mechanism.

Science, this issue p. 190, p. 194

View Full Text

Stay Connected to Science