Research Article

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

See allHide authors and affiliations

Science  08 Jan 2021:
Vol. 371, Issue 6525, eabd4914
DOI: 10.1126/science.abd4914

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Glycylation regulates axonemal dyneins

Physiological functions of the microtubule cytoskeleton are expected to be regulated by a variety of posttranslational tubulin modifications. For instance, tubulin glycylation is almost exclusively found in cilia and flagella, but its role in the function of these organelles remains unclear. Gadadhar et al. now demonstrate in mice that glycylation, although nonessential for the formation of cilia and flagella, coordinates the beat waveform of sperm flagella. This activity is a prerequisite for progressive sperm swimming and thus for male fertility. At the ultrastructural level, lack of glycylation perturbed the distribution of axonemal dynein conformations, which may explain the observed defects in flagellar beat.

Science, this issue p. eabd4914

View Full Text

Stay Connected to Science