Research Article

HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

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Science  05 Feb 2021:
Vol. 371, Issue 6529, eabb4309
DOI: 10.1126/science.abb4309

Article Information

vol. 371 no. 6529

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History: 
  • Received for publication March 8, 2020
  • Resubmitted October 5, 2020
  • Accepted for publication December 2, 2020
  • .

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Author Information

  1. Haiyang Yu1,*,
  2. Shan Lu1,,
  3. Kelsey Gasior2,3,,,
  4. Digvijay Singh4,
  5. Sonia Vazquez-Sanchez1,
  6. Olga Tapia5,6,
  7. Divek Toprani1,
  8. Melinda S. Beccari1,7,
  9. John R. Yates III8,
  10. Sandrine Da Cruz1,9,10,
  11. Jay M. Newby11,
  12. Miguel Lafarga5,6,12,
  13. Amy S. Gladfelter2,13,
  14. Elizabeth Villa4,
  15. Don W. Cleveland1,7,*
  1. 1Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
  2. 2Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  3. 3Department of Mathematics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  4. 4Division of Biological Sciences, University of California, San Diego, San Diego, CA, USA.
  5. 5Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
  6. 6Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Santander, Spain.
  7. 7Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.
  8. 8Departments of Molecular Medicine and Neurobiology, The Scripps Research Institute, La Jolla, CA, USA.
  9. 9VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  10. 10Department of Neurosciences, KU Leuven, Leuven, Belgium.
  11. 11Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, Alberta, Canada.
  12. 12Department of Anatomy and Cell Biology, University of Cantabria, Santander, Spain.
  13. 13Marine Biological Laboratory, Woods Hole, MA, USA.
  1. *Corresponding author. Email: dcleveland{at}ucsd.edu (D.W.C.); haiyang-yu{at}ucsd.edu (H.Y.)
  1. These authors contributed equally to this work.

  • Present address: Department of Mathematics, Florida State University, Tallahassee, FL, USA.

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Article usage: December 2020 to March 2021

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Dec 2020417522681098
Jan 202135862163832
Feb 2021665020461334
Mar 202114711076

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