Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease

Christina V. Theodoris; Ping Zhou; Lei Liu; Yu Zhang; Tomohiro Nishino; Yu Huang; Aleksandra Kostina; Sanjeev S. Ranade; Casey A. Gifford; Vladimir Uspenskiy; Anna Malashicheva; Sheng Ding; Deepak Srivastava

doi:10.1126/science.abd0724

Research Article

Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease

View ORCID ProfileChristina V. Theodoris ¹,²,³,
Ping Zhou¹,²,
Lei Liu¹,²,
Yu Zhang¹,²,
View ORCID ProfileTomohiro Nishino¹,²,
Yu Huang¹,²,
View ORCID ProfileAleksandra Kostina ⁴,
Sanjeev S. Ranade ¹,²,
View ORCID ProfileCasey A. Gifford ¹,²,
View ORCID ProfileVladimir Uspenskiy⁵,
View ORCID ProfileAnna Malashicheva ⁴,⁵,⁶,
View ORCID ProfileSheng Ding¹,²,⁷,
View ORCID ProfileDeepak Srivastava ¹,²,⁸,*

¹Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.
²Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.
³Program in Developmental and Stem Cell Biology (DSCB), University of California, San Francisco (UCSF), San Francisco, CA, USA.
⁴Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia.
⁵Almazov Federal Medical Research Centre, Saint Petersburg, Russia.
⁶Saint Petersburg State University, Saint Petersburg, Russia.
⁷Department of Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA.
⁸Department of Pediatrics, Department of Biochemistry and Biophysics, UCSF, San Francisco, CA, USA.

↵*Corresponding author. Email: dsrivastava{at}gladstone.ucsf.edu

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Science 12 Feb 2021:
Vol. 371, Issue 6530, eabd0724
DOI: 10.1126/science.abd0724

Christina V. Theodoris

1Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

2Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.

3Program in Developmental and Stem Cell Biology (DSCB), University of California, San Francisco (UCSF), San Francisco, CA, USA.

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ORCID record for Christina V. Theodoris

Ping Zhou

1Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

2Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.

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Lei Liu

1Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

2Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.

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Yu Zhang

1Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

2Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.

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Tomohiro Nishino

1Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

2Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.

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ORCID record for Tomohiro Nishino

Yu Huang

1Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

2Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.

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Aleksandra Kostina

4Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia.

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ORCID record for Aleksandra Kostina

Sanjeev S. Ranade

1Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

2Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.

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Casey A. Gifford

1Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

2Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.

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Vladimir Uspenskiy

5Almazov Federal Medical Research Centre, Saint Petersburg, Russia.

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Anna Malashicheva

4Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia.

5Almazov Federal Medical Research Centre, Saint Petersburg, Russia.

6Saint Petersburg State University, Saint Petersburg, Russia.

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ORCID record for Anna Malashicheva

Sheng Ding

1Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

2Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.

7Department of Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA.

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Deepak Srivastava

1Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.

2Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA.

8Department of Pediatrics, Department of Biochemistry and Biophysics, UCSF, San Francisco, CA, USA.

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ORCID record for Deepak Srivastava
For correspondence: dsrivastava@gladstone.ucsf.edu

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