Regeneration

Stem cells relieve pressure

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Science  19 Feb 2021:
Vol. 371, Issue 6531, pp. 794-795
DOI: 10.1126/science.371.6531.794-c

In glaucoma, intraocular pressure damages innervation from the eye, resulting in irreversible blindness. The most common form of glaucoma is primary open-angle glaucoma (POAG), characterized by deterioration of the trabecular meshwork (TM) cells that encircles the base of the cornea. When Xiong et al. transplanted exogenous human trabecular meshwork stem cells (TMSCs) into a POAG mouse model, aqueous humor drained normally, intraocular pressed was reduced and the function of the retinal ganglion cells was preserved. TMSC transplantation also increased TM cellularity and promoted myocilin secretion, which reduced endoplasmic reticulum stress in the cells. These signs of TM tissue repair show promise for use of stem cells in the development of clinical treatments for glaucoma.

eLife 10, e63677 (2021).

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