Research Article

Absolute and arbitrary orientation of single-molecule shapes

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Science  19 Feb 2021:
Vol. 371, Issue 6531, eabd6179
DOI: 10.1126/science.abd6179

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Orienting origami binding

Directing self-assembly for devices will require placing nanocomponents not only in the correct position on a surface but also in particular orientations. Gopinath et al. designed an asymmetric DNA origami, a “small moon” shape that binds to lithographically patterned sites on silica to within 3° of a target orientation angle. The authors were able to position and orient a molecular dipole within the resonant mode of an optical cavity. More than 3000 DNA origami were arranged in a single fabrication step in 12 different orientations to create a simple polarimeter.

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