Optimizing age-specific vaccination

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Science  26 Feb 2021:
Vol. 371, Issue 6532, pp. 890-891
DOI: 10.1126/science.abg2334


  • Key determinants of age-based vaccination

    Epidemiological factors drive age-based vaccine optimization for influenza and COVID-19 with varying influence according to the mechanism and magnitude of the factor. When there are stark differences in mortality risk with age, or when the reproductive number R0 is high, older people are more likely to be prioritized for vaccination. By contrast, high vaccine efficacy, the amount of social contact among younger people, and widespread adherence to nonpharmaceutical interventions can shift prioritization toward younger ages.


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