Research Article

Targeting a neoantigen derived from a common TP53 mutation

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Science  05 Mar 2021:
Vol. 371, Issue 6533, eabc8697
DOI: 10.1126/science.abc8697

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vol. 371 no. 6533

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History: 
  • Received for publication May 28, 2020
  • Resubmitted November 30, 2020
  • Accepted for publication February 5, 2021
  • .

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Author Information

  1. Emily Han-Chung Hsiue1,2,3,*,
  2. Katharine M. Wright2,4,5,*,
  3. Jacqueline Douglass1,2,3,*,
  4. Michael S. Hwang1,2,3,
  5. Brian J. Mog1,2,3,6,
  6. Alexander H. Pearlman1,2,3,
  7. Suman Paul1,2,3,7,
  8. Sarah R. DiNapoli1,2,3,
  9. Maximilian F. Konig1,2,3,8,
  10. Qing Wang1,2,9,
  11. Annika Schaefer1,2,3,
  12. Michelle S. Miller2,4,5,,
  13. Andrew D. Skora1,2,,
  14. P. Aitana Azurmendi2,4,5,
  15. Michael B. Murphy10,
  16. Qiang Liu1,2,3,
  17. Evangeline Watson1,2,3,
  18. Yana Li4,
  19. Drew M. Pardoll5,7,
  20. Chetan Bettegowda1,3,11,
  21. Nickolas Papadopoulos1,3,5,12,
  22. Kenneth W. Kinzler1,3,5,
  23. Bert Vogelstein1,2,3,5,12,§,
  24. Sandra B. Gabelli4,7,13,§,
  25. Shibin Zhou1,3,5,§
  1. 1Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  2. 2Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  3. 3Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  4. 4Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  5. 5Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
  6. 6Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  7. 7Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  8. 8Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
  9. 9Complete Omics, Baltimore, MD 21227, USA.
  10. 10Cytiva, Marlborough, MA 01752, USA.
  11. 11Department of Neurosurgery, Johns Hopkins University School of Medicine, MD 21205, USA.
  12. 12Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  13. 13Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  1. §Corresponding author. Email: vogelbe{at}jhmi.edu (B.V.); gabelli{at}jhmi.edu (S.B.G.); sbzhou{at}jhmi.edu (S.Z.)
  1. * These authors contributed equally to this work.

  • Present address: Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, VIC 3052, Australia.

  • Present address: Lilly Biotechnology Center, Eli Lilly and Co, San Diego, CA 92121, USA.

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