Research Article

Gamma rhythm communication between entorhinal cortex and dentate gyrus neuronal assemblies

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Science  02 Apr 2021:
Vol. 372, Issue 6537, eabf3119
DOI: 10.1126/science.abf3119

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Brain region coordination in learning

Gamma-frequency oscillations have been hypothesized as a physiological mechanism of interregional communication in the brain. However, until now, all supporting data have been correlational and thus indirect. Fernández-Ruiz et al. examined gamma-frequency activity and spike coupling between the entorhinal cortex and hippocampal dentate gyrus during learning and after selective perturbation of gamma-frequency spike timing. They observed an integrated neuron, gamma-band, and task-specific organization of the entorhinal cortex–hippocampal circuits. These data demonstrate that specific, projected gamma-frequency oscillation patterns dynamically engage functionally related cell assemblies across brain regions in a task-specific manner.

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