Autoimmune Diversity

Population-level lupus

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Science  14 May 2021:
Vol. 372, Issue 6543, pp. 699-700
DOI: 10.1126/science.372.6543.699-f

Autoimmune diseases often show polygenic inheritance, making the identification of potential causal genetic variants difficult, especially across ancestrally divergent populations. Andreoletti et al. examined the transcriptomes of bulk immune cells from 120 systematic lupus erythematosus (SLE) patients of Asian and European ancestry. Disease-specific genetic signatures were revealed, as well as ancestrally associated differences in SLE molecular pathways and the role of gene expression variation in disease severity. Because SLE severity differs among populations, this study highlights the need to examine disease genetics in multiethnic cohorts for underlying differences and to explore the clinical treatment options for individuals of differing ancestries.

Commun. Biol. 4, 488 (2021).

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